Fatal pulmonary thromboembolism: how frequently might testing for hereditary thrombophilia be considered?
نویسندگان
چکیده
منابع مشابه
Thrombophilia and venous thromboembolism: implications for testing.
In the last decades, the knowledge on the etiology of venous thromboembolism (VTE) has increased tremendously. In approximately half of patients presenting with VTE, one or more thrombophilic defects can be identified. This has led to widespread testing for thrombophilia, despite the fact that, at present, it is unclear whether this should have therapeutic consequences. Here we review the curre...
متن کاملSevere Thrombophilia in Idiopathic Fatal Pulmonary Embolism
Article history: Received 16 February 2017 Accepted 16 February 2017 Available online 20 February 2017 physicians in the management of certain situations with high risk of thrombosis such as pregnancy, birth control, or any surgery. The anticoagulant function of antithrombin, protein C, and protein Smay be easily evaluated by functional tests. Unfortunately, biochemical-based blood testing for ...
متن کاملHereditary thrombophilia
Thrombophilia can be defined as a predisposition to form clots inappropriately. Thrombotic events during infancy and childhood are increasingly recognized as a significant source of mortality and morbidity. The predisposition to form clots can arise from genetic factors, acquired changes in the clotting mechanism, or, more commonly, an interaction between genetic and acquired factors. Since the...
متن کاملRight atrial thrombosis and pulmonary embolism after atrial septal defect repair: could it be hereditary thrombophilia?
A 3-year-old boy underwent surgical closure of a large ostium secundum atrial septal defect. This was complicated with extensive right atrial thrombus formation and pulmonary thromboembolism immediately following surgery. He was managed with emergency surgical thromboembolectomy and anticoagulation. However, new thrombus was formed again immediately. This prompted us to add thrombolysis to his ...
متن کاملPrevalence of Hereditary Thrombophilia in Patients Older Than 75 Years With Venous Thromboembolism Referred for Thrombophilia Screening.
BACKGROUND Few studies focused on genetic risk factors for venous thromboembolism (VTE) in the very elderly people. In patients aged 75 years and older with VTE referred for laboratory screening tests for thrombophilia, we aimed: (i) to estimate the F5G1691A and F2G20210A mutation prevalence; (ii) to compare prevalence rates with those of a control group; and (iii) to compare the prevalence rat...
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ژورنال
عنوان ژورنال: Pathology
سال: 2020
ISSN: 0031-3025
DOI: 10.1016/j.pathol.2020.01.359